Epidermal growth factor receptor (EGFR). Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
NCT03542799 -
Metastatic Colorectal Cancer
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Head and Neck Cancer
The following plot describes the target topology, highlighting the
position of the endo-, ecto- and transmembrane domains, as well as the
position of a signal peptide, when present. The last three rows describe
the position of potential epitopes, as well as phosphorylation and
glycosylation sites.