Description

Epidermal growth factor receptor (EGFR). Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.


Clinical trials

NCT03542799 - Metastatic Colorectal Cancer
NCT01818323 - Head and Neck Cancer


Target gene expression

The following plot describes the expression, in different tissues and TCGA cancers, of the different isoforms of the gene EGFR.


Target essentiality


Protein properties

The following plot describes the target topology, highlighting the position of the endo-, ecto- and transmembrane domains, as well as the position of a signal peptide, when present. The last three rows describe the position of potential epitopes, as well as phosphorylation and glycosylation sites.